Cialis
(tadalafil)
Tadalafil tablet taken 30+ minutes before sex, with effects lasting up to 36 hours. Take it only when needed or as a low daily dose, in 2.5, 5, 10 and 20 mg strengths.
LICENSED PHARMACY & UK-LICENSED DOCTORS · FREE DISCREET DELIVERY
SILDENAFIL · ORAL SPRAY · ERECTILE DYSFUNCTION
HEZKUEMOUTH SPRAY
4PUMPS USUAL DOSE
12.5MG PER PUMP
1USE PER DAY
~10DOSES PER BOTTLE
Hezkue is a prescription-only mouth spray used to treat erectile dysfunction (ED) in adult men. ED is when you cannot get, or keep, an erection firm enough for satisfactory sex.
ABOUT THE MEDICATION
WHAT IS HEZKUE?
Hezkue is a prescription-only mouth spray used to treat erectile dysfunction (ED) in adult men. ED is when you cannot get, or keep, an erection firm enough for satisfactory sex. Hezkue contains sildenafil, the same active ingredient as Viagra, but instead of a tablet it comes as a mint-flavoured liquid (an oromucosal suspension) that you spray onto your tongue and swallow.
Sildenafil belongs to a group of medicines called phosphodiesterase type 5 (PDE5) inhibitors, the same family that includes tadalafil (Cialis) and avanafil (Spedra).
KEY FACTS
NO TABLET TO SWALLOW
One practical advantage of Hezkue is that there is no tablet to swallow and no water is needed, which suits men who find tablets difficult or who prefer a more discreet option.
12.5MG PER PUMP
Each press of the pump delivers 12.5 mg of sildenafil, and your clinician will tell you how many pumps to use.
TAKEN ONLY WHEN NEEDED
Hezkue is taken only when you need it rather than every day. It treats the symptoms of ED but does not cure the condition.
WITH OR WITHOUT FOOD
Hezkue can be used with or without food, but it may take longer to work after a heavy meal.
AROUSAL STILL NEEDED
Hezkue only works if you are sexually stimulated. It will not cause an erection on its own.
How it works
01
FREE ONLINE CONSULTATION
For your health and safety, all prescription drugs available for purchase require approval from our licensed doctors through a free online consultation where you will be asked some questions about your symptoms and medical history.
02
DISCREET NEXT-DAY DELIVERY
Your information is confidential and will only be shared with your doctor who will determine if a prescription treatment is right for you. If your prescription treatment is approved, your order will be delivered to you with discreet packaging the next business day.
03
ONGOING CARE AND SUPPORT
As a FROM MARS customer, you will receive ongoing care and support from UK Doctors. You can send unlimited secure messages to your doctor from your account to discuss your treatment, progress, and possible adjustments of your treatment or dosage.
01
FREE ONLINE CONSULTATION
For your health and safety, all prescription drugs available for purchase require approval from our licensed doctors through a free online consultation where you will be asked some questions about your symptoms and medical history.
02
DISCREET NEXT-DAY DELIVERY
Your information is confidential and will only be shared with your doctor who will determine if a prescription treatment is right for you. If your prescription treatment is approved, your order will be delivered to you with discreet packaging the next business day.
03
ONGOING CARE AND SUPPORT
As a FROM MARS customer, you will receive ongoing care and support from UK Doctors. You can send unlimited secure messages to your doctor from your account to discuss your treatment, progress, and possible adjustments of your treatment or dosage.
HEZKUE
- Take about an hour before sex
- Use with or without food
- Median 25 minutes to an erection
- Can still help 4 to 5 hours after the dose
Take about an hour before sex
Use with or without food
Median 25 minutes to an erection
Can still help 4 to 5 hours after the dose
HOW HEZKUE WORKS
HOW DOES HEZKUE WORK?
When you are sexually aroused, your body releases a substance called nitric oxide in the penis. This raises the level of a chemical messenger called cGMP, which relaxes the muscle in the walls of the blood vessels so that blood can flow into the penis and produce an erection.
You Still Need Sexual Stimulation
Hezkue only works if you are sexually stimulated. It will not cause an erection on its own. It treats the symptoms of ED but does not cure the condition.
In Practice
WHAT HAPPENS WHEN YOU USE HEZKUE?
Sildenafil blocks PDE5
An enzyme called PDE5 normally breaks cGMP down. Sildenafil blocks PDE5, so cGMP lasts longer and it becomes easier to get and keep an erection.
Take about an hour before sex
Hezkue and Viagra are both taken about an hour before sex. A heavy meal may delay the time it takes to work.
Can still help 4 to 5 hours later
In men who had not eaten, the median time to an erection firm enough for sex was 25 minutes after dosing, and sildenafil could still help produce an erection 4 to 5 hours after the dose.
DOSING & HOW TO USE
HOW DO YOU TAKE HEZKUE?
01
Dose
The usual dose is 4 pumps (2 mL, equivalent to 50 mg of sildenafil), taken about an hour before sex, only when you need it.
02
Shake
Shake the bottle vigorously for about 20 seconds before every use.
03
Attach the pump
Remove the child-resistant cap by pushing it down and turning it anticlockwise. Slide the pump's plastic tube into the bottle and screw the pump on clockwise until it is secure, then turn the nozzle to the open position.
04
Prime
Before every dose, including the first, prime the pump by pressing it 3 times into a tissue and throwing that liquid away. If you skip this step you may get a lower dose.
05
Spray and swallow
Tilt your head back slightly, open your mouth and hold the bottle near your chin. Press the pump the number of times your clinician has prescribed, spraying onto your tongue, then swallow straight away with your saliva. Try not to let the nozzle touch your mouth or tongue.
06
Close
Turn the nozzle to the closed position, unscrew the pump, tap the tube against the inside of the bottle to remove excess liquid and replace the cap straight away.
07
Wash and dry
Wash the pump with water, press it several times into a tissue to clear it, and let it dry fully before next use.
08
Mouth only
Hezkue is for use in the mouth only. Do not spray it into your nose or onto your skin.
Side Effects
POSSIBLE SIDE EFFECTS
OF HEZKUE
Most side effects of Hezkue are mild to moderate.
FREQUENCY
SIDE EFFECTS
WHAT TO DO
VERY COMMON — MORE THAN 1 IN 10
The most common is headache, which may affect more than 1 in 10 people.
Speak to your healthcare provider about any side effects that trouble you, get worse or do not go away.
COMMON — UP TO 1 IN 10
Other common side effects, which may affect up to 1 in 10 people, include flushing, indigestion, feeling sick, a blocked nose, dizziness, blurred vision and changes to colour vision (such as a blue tinge).
Hezkue can cause dizziness and affect your vision. Be aware of how you react to it before you drive or use machinery.
LESS COMMON
Less common side effects include vomiting, a fast or pounding heartbeat, dry mouth, muscle aches, a runny or blocked nose and nosebleeds.
These are not all of the possible side effects.
Get medical help straight away if you notice any of the following: • an erection that lasts more than 4 hours (priapism), which must be treated quickly to avoid lasting damage to the penis • a sudden decrease or loss of vision • a sudden decrease or loss of hearing • signs of a serious skin reaction, such as severe peeling or swelling of the skin, blisters in the mouth, bumps on the genitals or around the eyes, or fever • seizures or fits If you get chest pain during or after sex, get into a semi-sitting position, try to relax and contact a doctor immediately. Do not use a nitrate to treat the chest pain, and tell the medical team that you have used Hezkue and when. Stop using Hezkue and get medical help immediately if you show signs of a serious allergic reaction, such as sudden wheezing, shortness of breath, dizziness, or swelling of the eyelids, face, lips or throat.
EFFECTIVENESS
HOW EFFECTIVE IS HEZKUE?
Fixed-dose studies
82%
of men taking 100 mg reported improved erections
In fixed-dose studies, 62% of men taking 25 mg, 74% taking 50 mg and 82% taking 100 mg reported that their erections improved, compared with 25% on placebo.
Other health conditions
69%
of men with heart disease reported improvements
Sildenafil also worked for many men with other health conditions, with improvements reported by 59% of men with diabetes, 68% of men with high blood pressure and 69% of men with heart disease.
Over 8,000 men studied
How well Hezkue works varies from person to person and depends on your dose and your general health. Hezkue contains sildenafil, which has been studied in clinical trials involving more than 8,000 men aged 19 to 87.
HEZKUE DOSAGE
& STRENGTH
Hezkue comes as a 30 mL bottle in one strength: each pump delivers 12.5 mg of sildenafil. The usual dose is 4 pumps (50 mg), which can be lowered to 2 pumps (25 mg) or raised to 8 pumps (100 mg).
DOSE
WHEN IT'S USED
NOTES
2 pumps (25 mg)
Lower dose, if your clinician advises it
Kidney and liver problems: your clinician may start you on a lower dose.
4 pumps (50 mg)
The usual dose
At the usual dose of 4 pumps, each 30 mL bottle provides about 10 doses.
8 pumps (100 mg)
The maximum dose in a day
Never use Hezkue more than once a day, and never take more than 8 pumps (100 mg) in a day.
What to Expect
WHAT TO EXPECT:
YOUR HEZKUE TIMELINE
1 hour before
Hezkue and Viagra are both taken about an hour before sex. A heavy meal may delay the time it takes to work.
25 minutes
In men who had not eaten, the median time to an erection firm enough for sex was 25 minutes after dosing, and sildenafil could still help produce an erection 4 to 5 hours after the dose.
Once a day
Never use Hezkue more than once a day, and never take more than 8 pumps (100 mg) in a day.
Compare
HEZKUE VS
VIAGRA VS CIALIS
RELATED TREATMENTS.
Real medication. Real doctors. No inflated prices. Just results.
Viagra
(sildenafil)
The original ED tablet. Sildenafil is taken about 1 hour before sex, only when needed, and comes in 25, 50 and 100 mg strengths. Prescribed online after a clinician review.
Spedra
(avanafil)
Avanafil tablet and one of the fastest-acting ED treatments, able to start working in around 15 minutes. Taken only when needed, prescribed online after a clinician review.
New — MHRA approved June 2026
Wegovy Tablets
(oral semaglutide)
New for 2026. The UK's first once-daily GLP-1 weight loss tablet, MHRA-approved in June 2026. The same active ingredient as the Wegovy injection, with comparable weight loss in trials — no needles required.
Price includes medication only, if prescribed. An active FromMars membership is required and billed separately. Membership does not include or guarantee a prescription; medication is not available without a membership.
Drug and food interactions
HEZKUE INTERACTIONS
Nitrates and poppers
Never use Hezkue with nitrate medicines or nitric oxide donors such as amyl nitrite, as the combination can cause a dangerous drop in blood pressure.
Nicorandil
This angina medicine contains a nitrate component and can cause a serious interaction with sildenafil.
Grapefruit
Grapefruit juice may modestly increase sildenafil levels.
Riociguat
Must not be used with Hezkue.
Ritonavir
Using Hezkue with the HIV medicine ritonavir is not advised.
CYP3A4 inhibitors
Medicines such as ketoconazole, itraconazole, erythromycin, cimetidine and some HIV medicines increase sildenafil levels, so a starting dose of 2 pumps (25 mg) should be considered.
Sacubitril/ valsartan
Tell your clinician if you take this heart failure medicine, as extra caution is needed when starting Hezkue.
Other ED treatments
Do not use Hezkue with any other medicine containing sildenafil (including sildenafil for pulmonary arterial hypertension) or any other treatment for erectile dysfunction.
Everything you take
Always tell your healthcare provider about everything you take, including prescription medicines, over-the-counter products, vitamins and herbal supplements.
ELIGIBILITY
WHO CAN TAKE HEZKUE?
WHO HEZKUE IS FOR
Hezkue is for men aged 18 and over who have erectile dysfunction. It is not for women, and it will not help if you do not have ED. Before prescribing, a FromMars clinician will review your medical history, your heart health, your blood pressure and any other medicines you take.
YOU MUST NOT USE HEZKUE IF YOU
• take any form of nitrate medicine for chest pain (angina), such as glyceryl trinitrate (GTN), or use nitric oxide donors such as amyl nitrite ("poppers") • take riociguat, a medicine for high blood pressure in the lungs • are allergic to sildenafil or any of the other ingredients
HAVE A HEART, BLOOD PRESSURE OR LIVER PROBLEM
• have a heart condition that makes sexual activity inadvisable, such as unstable angina or severe heart failure • have recently had a stroke or a heart attack • have low blood pressure (below 90/50 mmHg) • have severe liver problems
HAVE AN INHERITED EYE CONDITION OR VISION LOSS
• have lost sight in one eye because of non-arteritic anterior ischaemic optic neuropathy (NAION) • have an inherited degenerative eye condition such as retinitis pigmentosa
Safety
WARNINGS AND PRECAUTIONS
Drinking alcohol can temporarily make it harder to get an erection. To get the most from your medicine, avoid drinking large amounts of alcohol before using Hezkue.
- 01
Heart health
Sexual activity puts some strain on the heart. Your clinician will consider your heart health before prescribing. Men with narrowing of the heart's outflow valve (aortic stenosis), hypertrophic obstructive cardiomyopathy or multiple system atrophy can be particularly sensitive to medicines like Hezkue. Serious heart and circulation events have been reported rarely, mostly in men with existing heart problems.
- 02
Prolonged erections
Seek immediate medical help if an erection lasts longer than 4 hours. Hezkue should be used with caution if you have a condition affecting the shape of your penis (such as Peyronie's disease) or a condition that increases the risk of priapism (such as sickle cell anaemia, multiple myeloma or leukaemia).
- 03
Vision problems
Visual changes, including NAION, have been reported with sildenafil and other PDE5 inhibitors. Stop using Hezkue and contact a doctor immediately if your vision suddenly changes.
- 04
Alpha-blockers
Taking Hezkue with an alpha-blocker can cause dizziness or light-headedness, most often within 4 hours of the dose. You should be on a stable dose of your alpha-blocker first, and your clinician may start you on 2 pumps (25 mg).
- 05
Bleeding and ulcers
Hezkue should only be used after a careful assessment if you have a bleeding disorder (such as haemophilia) or an active stomach ulcer.
- 06
Kidney and liver
Your clinician may start you on a lower dose.
- 07
Driving
Hezkue can cause dizziness and affect your vision. Be aware of how you react to it before you drive or use machinery.
- 08
Women and under-18s
Hezkue is not for use by women or by anyone under 18.
Ongoing Care
HOW OFTEN WILL I CHECK IN WITH A CLINICIAN?
Before your first prescription, a FromMars clinician reviews your consultation, including your heart health, blood pressure and other medicines. Each time you reorder, you will be asked to confirm whether anything has changed, such as a new diagnosis or a new medicine.
If you need extra support at any point, whether about side effects, changing your dose, switching medicines or anything else, you can message one of our clinicians.
ED and your wider health
ED can sometimes be an early sign of other health problems, such as heart disease, high blood pressure, raised cholesterol or diabetes, so it is worth having these checked with your GP. Lifestyle changes such as stopping smoking, cutting down on alcohol, staying active and keeping to a healthy weight can also improve erections over time.
Houston,
we have answers.
Houston,
we have answers.
Availability
IS HEZKUE AVAILABLE IN THE UK?
Yes. Hezkue is licensed in the UK by the MHRA and is available on prescription. FromMars can prescribe Hezkue following an online consultation with one of our clinicians, if it is suitable for you.
READY TO START?
GET HEZKUE
TODAY
FROM MARS is a registered UK pharmacy so start your online consultation here. If our doctors determine that it is a medically appropriate treatment for you, you’ll get a prescription treatment plan within two hours. We’ll ship your meds to you the next day.