Sildenafil
(generic Viagra)
The generic version of Viagra, with the same active ingredient for less. Take it about an hour before sex and it works for up to 4 hours. MHRA-approved.
LICENSED PHARMACY & UK-LICENSED DOCTORS · FREE DISCREET DELIVERY
AVANAFIL · PDE5 INHIBITOR · ERECTILE DYSFUNCTION TABLET
SPEDRATABLETS
1TABLET PER 24 HOURS
100MG STARTING DOSE
3STRENGTHS
15-30MINS BEFORE SEX
Spedra is the brand name for avanafil, a prescription-only tablet used to treat erectile dysfunction (ED) in adult men. ED is when you cannot get, or keep, an erection firm enough for satisfactory sex.
ABOUT THE MEDICATION
WHAT IS SPEDRA?
Spedra is the brand name for avanafil, a prescription-only tablet used to treat erectile dysfunction (ED) in adult men. ED is when you cannot get, or keep, an erection firm enough for satisfactory sex. Avanafil belongs to a group of medicines called phosphodiesterase type 5 (PDE5) inhibitors, the same family that includes sildenafil (Viagra) and tadalafil (Cialis).
One practical advantage of Spedra is speed. It is licensed to be taken approximately 15 to 30 minutes before sex, compared with around an hour for sildenafil, and it can be taken with or without food. Spedra is taken only when you need it rather than every day. It treats the symptoms of ED but does not cure the condition.
KEY FACTS
THREE STRENGTHS
Spedra tablets contain avanafil and come in three strengths: 50 mg, 100 mg and 200 mg. The usual starting dose is 100 mg.
PRESCRIPTION ONLY
Spedra is licensed in the UK by the MHRA and is available on prescription.
15 TO 30 MINUTES BEFORE SEX
Spedra is taken approximately 15 to 30 minutes before sex (about 30 minutes for the 50 mg dose).
WITH OR WITHOUT FOOD
Spedra can be taken with or without food, although a high-fat meal may delay the time it takes to work.
AROUSAL STILL NEEDED
Spedra only works if you are sexually stimulated. It will not cause an erection on its own, so you and your partner will still need foreplay, just as you would without medicine.
How it works
01
FREE ONLINE CONSULTATION
For your health and safety, all prescription drugs available for purchase require approval from our licensed doctors through a free online consultation where you will be asked some questions about your symptoms and medical history.
02
DISCREET NEXT-DAY DELIVERY
Your information is confidential and will only be shared with your doctor who will determine if a prescription treatment is right for you. If your prescription treatment is approved, your order will be delivered to you with discreet packaging the next business day.
03
ONGOING CARE AND SUPPORT
As a FROM MARS customer, you will receive ongoing care and support from UK Doctors. You can send unlimited secure messages to your doctor from your account to discuss your treatment, progress, and possible adjustments of your treatment or dosage.
01
FREE ONLINE CONSULTATION
For your health and safety, all prescription drugs available for purchase require approval from our licensed doctors through a free online consultation where you will be asked some questions about your symptoms and medical history.
02
DISCREET NEXT-DAY DELIVERY
Your information is confidential and will only be shared with your doctor who will determine if a prescription treatment is right for you. If your prescription treatment is approved, your order will be delivered to you with discreet packaging the next business day.
03
ONGOING CARE AND SUPPORT
As a FROM MARS customer, you will receive ongoing care and support from UK Doctors. You can send unlimited secure messages to your doctor from your account to discuss your treatment, progress, and possible adjustments of your treatment or dosage.
SPEDRA®
- Take 15 to 30 minutes before sex
- With or without food
- Three strengths: 50, 100 and 200 mg
- No more than one tablet in 24 hours
Take 15 to 30 minutes before sex
With or without food
Three strengths: 50, 100 and 200 mg
No more than one tablet in 24 hours
How Spedra Works
HOW DOES SPEDRA WORK?
When you are sexually aroused, your body releases a substance called nitric oxide in the penis. This raises the level of a chemical messenger called cGMP, which relaxes the muscle in the walls of the blood vessels so that blood can flow into the penis and produce an erection.
You Still Need Sexual Stimulation
Spedra only works if you are sexually stimulated. It will not cause an erection on its own, so you and your partner will still need foreplay, just as you would without medicine.
In Practice
WHAT HAPPENS WHEN YOU TAKE SPEDRA?
It blocks PDE5
An enzyme called PDE5 normally breaks cGMP down. Spedra blocks PDE5, so cGMP lasts longer and it becomes easier to get and keep an erection.
It can work in around 15 minutes
In a study designed to test how quickly it works, some men were able to have successful sex around 15 minutes after taking Spedra. These benefits were maintained in longer-term studies.
A high-fat meal may slow it down
Spedra can be taken with or without food, but it may take longer to work after a meal, particularly a high-fat one.
Dosing & How to Take
HOW DO YOU TAKE SPEDRA?
01
Dose
The usual starting dose is one 100 mg tablet, swallowed approximately 15 to 30 minutes before sex, only when you need it.
02
Adjusting
Depending on how well it works and how well you tolerate it, your clinician may increase the dose to 200 mg or lower it to 50 mg. The 50 mg tablet is taken about 30 minutes before sex.
03
Food
Spedra can be taken with or without food, but it may take longer to work after a meal, particularly a high-fat one.
04
Maximum
Never take more than one tablet in 24 hours. If you take more Spedra than you should, tell your doctor straight away, as you may get more side effects and they may be more severe.
Side Effects
POSSIBLE SIDE EFFECTS
OF SPEDRA
Most side effects of Spedra are mild to moderate.
FREQUENCY
SIDE EFFECTS
WHAT TO DO
COMMON — UP TO 1 IN 10
Headache, flushing and a blocked or stuffy nose
These are not all of the possible side effects. Speak to your healthcare provider about any side effects that trouble you, get worse or do not go away.
LESS COMMON
Dizziness, feeling sleepy or tired, sinus congestion, back pain, hot flushes, breathlessness on exertion, a faster or pounding heartbeat, indigestion, feeling or being sick and blurred vision
Get medical help immediately if you show signs of a serious allergic reaction, such as swelling of the face, lips, tongue or throat, difficulty breathing or a severe rash.
STOP & SEE A DOCTOR
An erection that lasts more than 4 hours (priapism), which must be treated quickly to avoid lasting damage to the penis
Blurred vision, or a sudden decrease or loss of vision in one or both eyes
A sudden decrease or loss of hearing, which may come with dizziness or ringing in the ears
If you get chest pain during or after sex, stop, rest and get urgent medical help. Tell the medical team that you have taken Spedra and when, because some treatments for chest pain (nitrates) can cause a dangerous drop in blood pressure if given soon after Spedra.
Drinking alcohol at the same time as taking Spedra may lower your blood pressure and increase your heart rate, making you feel dizzy (especially when standing up), giving you a headache or making you aware of your heartbeat. Alcohol can also make it harder to get an erection.
Effectiveness
HOW EFFECTIVE IS SPEDRA?
General population
58%
of attempts successful on 100 mg, vs around 28% on placebo
In men with ED in the general population, around 47%, 58% and 59% of attempts at sex were successful with the 50 mg, 100 mg and 200 mg doses respectively, compared with around 28% on placebo.
Men with diabetes
40%
of attempts successful on 200 mg, vs 21% on placebo
In men with type 1 or type 2 diabetes, around 34% (100 mg) and 40% (200 mg) of attempts were successful, compared with 21% on placebo.
Clinical trials
How well Spedra works varies from person to person and depends on your dose and your general health. In four randomised, placebo-controlled trials involving 1,774 men taking avanafil, all three strengths led to significantly more successful attempts at sex than placebo.
Spedra was also effective in men with ED after nerve-sparing prostate surgery.
Spedra dosage
& strength
Spedra tablets contain avanafil and come in three strengths: 50 mg, 100 mg and 200 mg. The usual starting dose is 100 mg. Never take more than one tablet in 24 hours.
STRENGTH
WHO IT'S FOR
NOTES
50 mg
Lower dose
The 50 mg tablet is taken about 30 minutes before sex.
100 mg
The usual starting dose
The usual starting dose is one 100 mg tablet, swallowed approximately 15 to 30 minutes before sex, only when you need it.
200 mg
Higher dose
Depending on how well it works and how well you tolerate it, your clinician may increase the dose to 200 mg or lower it to 50 mg.
What to Expect
What to Expect:
Your Spedra Timeline
15 to 30 min
The usual starting dose is one 100 mg tablet, swallowed approximately 15 to 30 minutes before sex, only when you need it.
30 minutes
The 50 mg tablet is taken about 30 minutes before sex.
15 minutes
In a study designed to test how quickly it works, some men were able to have successful sex around 15 minutes after taking Spedra.
24 hours
Never take more than one tablet in 24 hours.
Compare
HOW IS SPEDRA DIFFERENT
FROM VIAGRA AND CIALIS?
RELATED TREATMENTS.
Real medication. Real doctors. No inflated prices. Just results.
Tadalafil
(generic Cialis)
The generic version of Cialis. Takes effect in about 2 hours and lasts up to 36 hours, so there is less need to plan around sex. Take as needed or as a low daily dose. MHRA-approved.
Vardenafil
(generic Levitra)
The generic version of Levitra. Can start working within 25 minutes to an hour and may last 4 to 5 hours. Many men find it works quicker than other ED tablets. MHRA-approved.
Viagra
(sildenafil)
The original branded ED tablet, containing sildenafil. Take it about an hour before sex and it works for up to 4 hours. Available in 25 mg, 50 mg and 100 mg strengths.
Cialis
(tadalafil)
Branded tadalafil, often called the weekend pill. Takes effect in about 2 hours and lasts up to 36 hours. Take it as needed or as a low daily dose, in strengths from 2.5 mg to 20 mg.
Price includes medication only, if prescribed. An active FromMars membership is required and billed separately. Membership does not include or guarantee a prescription; medication is not available without a membership.
Drug Interactions
Spedra Interactions
Nitrates and poppers
Never take Spedra with nitrate medicines or nitric oxide donors such as amyl nitrite, as the combination can cause a dangerous drop in blood pressure.
Riociguat
Must not be taken with Spedra.
Strong CYP3A4 inhibitors
Must not be taken with Spedra (see Contraindications above).
Moderate CYP3A4 inhibitors
With medicines such as erythromycin, diltiazem, verapamil, fluconazole or aprepitant, do not take more than 100 mg of Spedra and leave at least 48 hours between doses.
Alpha-blockers
You should be stable on your alpha-blocker before starting Spedra, and start at the lowest dose of 50 mg.
Medicines that may make Spedra less effective
Such as carbamazepine, phenobarbital, primidone, rifampicin, bosentan and efavirenz. Using these together is not recommended.
Other medicines
Tell your clinician if you take medicines for an irregular heartbeat, such as quinidine, procainamide, amiodarone or sotalol.
Grapefruit juice
Avoid for 24 hours before taking Spedra.
Other ED treatments
Do not use Spedra with any other medicine or treatment for erectile dysfunction.
Everything you take
Always tell your healthcare provider about everything you take, including prescription medicines, over-the-counter products, vitamins and herbal supplements.
WARNINGS
Who can take Spedra?
WHO IT IS FOR
Spedra is for men aged 18 and over who have erectile dysfunction. It is not for women, and it will not help if you do not have ED. Before prescribing, a FromMars clinician will review your medical history, your heart health, your blood pressure and any other medicines you take. It is not the right medicine for everyone.
YOU MUST NOT TAKE SPEDRA IF YOU:
• take any form of nitrate medicine for chest pain (angina), such as glyceryl trinitrate (GTN), or use nitric oxide donors such as amyl nitrite ("poppers") • take riociguat, a medicine for high blood pressure in the lungs • take certain strong medicines that stop the body breaking down Spedra, including ritonavir, atazanavir, indinavir, nelfinavir and saquinavir (for HIV), ketoconazole, itraconazole and voriconazole (for fungal infections), clarithromycin and telithromycin (antibiotics) and nefazodone
HEART AND BLOOD PRESSURE
• have had a heart attack, a stroke or a life-threatening irregular heartbeat in the last 6 months • have low blood pressure (below 90/50 mmHg) or high blood pressure above 170/100 mmHg • have unstable angina, get chest pain during sex, or have heart failure that causes symptoms during ordinary activity
LIVER, KIDNEYS AND EYES
• have severe liver problems or severe kidney problems • have lost sight in one eye because of non-arteritic anterior ischaemic optic neuropathy (NAION) • have an inherited degenerative eye condition such as retinitis pigmentosa
ALLERGY
• are allergic to avanafil or any of the other ingredients
Safety
Warnings and precautions
Spedra is not for use by women or by anyone under 18.
- 01
Heart and blood pressure
Heart health: sexual activity puts some strain on the heart. Your clinician will consider your heart health before prescribing. Men with narrowing of the heart's outflow valve (aortic stenosis) or similar conditions can be particularly sensitive to medicines like Spedra. Low blood pressure: Spedra can lower blood pressure slightly. Taking it with alpha-blockers, other blood pressure medicines or alcohol increases the chance of dizziness or fainting.
- 02
Priapism and bleeding
Prolonged erections (priapism): seek immediate medical help if an erection lasts 4 hours or more. Spedra should be used with caution if you have a condition affecting the shape of your penis (such as Peyronie's disease) or a condition that increases the risk of priapism (such as sickle cell anaemia, multiple myeloma or leukaemia). Bleeding disorders and stomach ulcers: Spedra should only be used after a careful assessment if you have a bleeding disorder or an active stomach ulcer.
- 03
Vision and hearing
Vision problems: visual changes, including central serous chorioretinopathy and NAION, have been reported with PDE5 inhibitors. Stop taking Spedra and contact a doctor immediately if your vision suddenly changes. Sudden hearing loss: stop taking Spedra and seek prompt medical attention if your hearing suddenly decreases or is lost.
- 04
Driving
Spedra can cause dizziness or affect your vision. If this happens, do not drive, cycle or use tools or machines.
Ongoing Care
Checking in with a clinician
Before your first prescription, a FromMars clinician reviews your consultation, including your heart health, blood pressure and other medicines. Each time you reorder, you will be asked to confirm whether anything has changed, such as a new diagnosis or a new medicine.
ED can sometimes be an early sign of other health problems, such as heart disease, high blood pressure, raised cholesterol or diabetes, so it is worth having these checked with your GP. Lifestyle changes such as stopping smoking, cutting down on alcohol, staying active and keeping to a healthy weight can also improve erections over time.
If you need extra support
If you need extra support at any point, whether about side effects, changing your dose, switching medicines or anything else, you can message one of our clinicians.
Houston,
we have answers.
Houston,
we have answers.
Availability
How much does Spedra cost?
Spedra is licensed in the UK by the MHRA and is available on prescription. FromMars can prescribe Spedra following an online consultation with one of our clinicians, if it is suitable for you. The price depends on the strength and the number of tablets you choose, and is shown on the Spedra product page.
READY TO START?
GET SPEDRA®
TODAY
FROM MARS is a registered UK pharmacy so start your online consultation here. If our doctors determine that it is a medically appropriate treatment for you, you’ll get a prescription treatment plan within two hours. We’ll ship your meds to you the next day.