Mounjaro
(tirzepatide)
Once-weekly injection. The only dual-action GIP and GLP-1 treatment, with the strongest results seen in clinical trials — average weight loss of 20% or more at higher doses over 72 weeks. MHRA-licensed.
LICENSED PHARMACY & UK-LICENSED DOCTORS · FREE DISCREET DELIVERY
SEMAGLUTIDE · NOVO NORDISK · DAILY ORAL GLP-1
NEWFree discreet delivery
*Individual results vary and all trial results included lifestyle support.
The weight loss revolution, without the needle. Wegovy tablets are the UK's first licensed daily GLP-1 weight loss pill — approved by the MHRA in June 2026 — delivering the proven effects of semaglutide in a once-daily tablet, with weight loss in trials comparable to the weekly Wegovy injection.
ABOUT THE MEDICATION
Wegovy tablets contain semaglutide — the same active ingredient as the Wegovy weekly injection — as a once-daily oral tablet. On 11 June 2026 the MHRA approved them for weight management, making the UK the first country in Europe to license a daily GLP-1 weight loss pill, with private availability from July 2026.
They're licensed for adults with a BMI of 30+, or 27+ with at least one weight-related condition (type 2 diabetes, hypertension, high cholesterol, sleep apnoea, cardiovascular disease), alongside a reduced-calorie diet and increased physical activity.
KEY BENEFITS
The same active ingredient as the Wegovy weekly injection, as a once-daily oral tablet.
Over 64 weeks, average weight loss was around 13–14% — results comparable to the 2.4 mg weekly injection.
MHRA-approved on 11 June 2026, the first daily GLP-1 weight loss pill licensed in the UK.
An absorption enhancer that creates a locally protective environment at the stomach lining so a portion of the dose crosses intact.
GLP-1 weight loss treatments are licensed for adults who meet one of the following criteria, alongside a reduced-calorie diet and increased physical activity:
BMI thresholds may be adjusted for people from South Asian, Chinese, other Asian, Middle Eastern, Black African or African-Caribbean backgrounds, who are at higher cardiometabolic risk at lower BMIs.
Meeting the BMI criteria alone doesn't guarantee suitability — our prescribers review your full medical history. GLP-1 treatments are not suitable during pregnancy or breastfeeding, or for people with a personal or family history of medullary thyroid carcinoma or MEN 2, among other contraindications your prescriber will assess.
Basic Info
What is your height?
What is your weight?
SNAC absorption technology
25 mg daily maintenance dose
Once daily — no injections
MHRA approved June 2026
TRIAL WEIGHT LOSS RESULTS
~13–14%
average weight loss over 64 weeks OASIS 4 trial (25 mg oral semaglutide)
Cross-trial comparisons are indicative only; individual results vary and all trial results included lifestyle support.
What Are They?
Semaglutide is a peptide, and stomachs destroy peptides — that's why GLP-1 medicines have historically been injections. Wegovy tablets solve this with SNAC, an absorption enhancer that creates a locally protective environment at the stomach lining so a portion of the dose crosses intact. It works — but only under precise conditions, which is why the taking-it-correctly routine below isn't optional advice; it's the mechanism.
How It Works
Semaglutide mimics GLP-1, the fullness hormone released after eating: appetite drops, the mental 'food noise' quietens, the stomach empties more slowly so meals satisfy for hours, and blood sugar steadies. The tablet delivers the identical mechanism to the injection — the only difference is the route in.
Appetite drops and the mental 'food noise' quietens.
The stomach empties more slowly so meals satisfy for hours, and blood sugar steadies.
Daily dosing also means steady drug levels with a shorter tail: some patients prefer knowing that if side effects bite or plans change, the medicine clears faster than a weekly depot injection.
Rybelsus is oral semaglutide licensed for type 2 diabetes at up to 14 mg daily. Wegovy tablets carry a separate licence for weight management at up to 25 mg daily. Same molecule, different licences, doses and indications — not interchangeable without prescriber guidance.
This Determines Your Results
Take your tablet when you wake, before anything else — food, coffee, other tablets, everything.
No more than about 120 ml (half a glass). More water dilutes the protective SNAC environment and cuts absorption. Plain water only — not juice, tea or sparkling.
Never split, crush or chew — the tablet's integrity is part of the delivery system.
No food, no other drinks, no other medicines for a minimum of 30 minutes. Longer is fine; shorter costs you dose.
After the wait, eat breakfast and take other medicines as usual.
Morning coffee 'just this once' before the wait is up — caffeine habits are the number one adherence killer; keep the kettle for minute 31.
Taking it with other morning tablets — levothyroxine, PPIs and supplements all belong after the 30 minutes (levothyroxine users: see interactions below).
A full glass of water 'to be safe' — counterintuitively, more water means less absorption.
Unpredictable wake times — the tablet suits routines; if your mornings are chaos, be honest with yourself and consider the weekly injection instead.
Side Effects
Nausea, diarrhoea, constipation, vomiting
Reflux, bloating, burping, headache, fatigue, dizziness, hair shedding
Gallstones, gallbladder inflammation, raised heart rate, hypoglycaemia (with diabetes medicines)
Pancreatitis, severe allergic reaction, dehydration from prolonged vomiting
The profile mirrors the injection — same molecule, same class effects. Tell any clinician before planned surgery or sedation that you take semaglutide (slowed stomach emptying is relevant to anaesthesia), and report suspected side effects via the MHRA Yellow Card scheme.
The Evidence
~13–14%
average weight loss vs ~2% placebo over 64 weeks with a substantial proportion losing 15%+
The MHRA approval rests on OASIS 4, a phase 3 trial of oral semaglutide 25 mg in adults with obesity or overweight plus a comorbidity. Over 64 weeks, average weight loss was around 13–14% versus roughly 2% with placebo, with a substantial proportion of participants losing 15% or more — results comparable to the 2.4 mg weekly injection, and the basis for the MHRA permitting direct switching between the two.
~15%
at 50 mg dose (OASIS 1)
Earlier OASIS trials tested oral semaglutide up to 50 mg, with OASIS 1 showing ~15% average loss at that dose — evidence that the oral route can fully match injections. The licensed UK dose is 25 mg, chosen for its balance of efficacy and tolerability.
Cross-trial comparisons are indicative only; individual results vary and all trial results included lifestyle support.
Wegovy tablets are titrated from a 1.5 mg starting dose to the 25 mg daily maintenance dose over four months.
Skip it and take your next tablet at the usual time tomorrow — never take two in one day, and never take one later in the day after eating (it won't absorb properly anyway).
The MHRA permits patients established on the 2.4 mg weekly injection to move directly to the 25 mg tablet without re-titrating. Take the first tablet up to 7 days after the final injection. Switching tablet-to-injection is equally manageable — plan either move with your prescriber.
Progress Over Time
1.5 mg
Tolerance-building dose; appetite changes usually begin within one to two weeks, scale movement modest.
4 mg → 9 mg
Steady visible loss; brief side-effect flurries around each step-up are normal and settle.
25 mg
Full dose reached — the steepest part of the curve for most patients. Protein and strength training matter most now.
25 mg
Gradual continued loss toward the trial average, then plateau — the cue for a maintenance conversation, not a sign of failure.
FULL RANGE
Real medication. Real doctors. No inflated prices. Just results.
Price includes medication only, if prescribed. An active FromMars membership is required and billed separately. Membership does not include or guarantee a prescription; medication is not available without a membership.
Drug Interactions
Oral semaglutide increases levothyroxine exposure — thyroid monitoring is advised, and the 30-minute separation is essential. Flag thyroid medication in your consultation.
Take them after the 30-minute window — both to protect semaglutide absorption and theirs. Slowed stomach emptying can also modestly alter absorption of narrow-window drugs (e.g. warfarin); monitoring can be arranged.
Insulin or sulfonylurea doses often need reducing to avoid hypoglycaemia.
No direct interaction; the usual advice — it aggravates nausea and adds calories, and tolerance often drops.
WARNINGS
stop at least two months before a planned pregnancy.
severe GI disease including gastroparesis, or alongside any other GLP-1 medicine.
diabetic retinopathy, and severe renal or hepatic impairment.
(e.g. medicines that must be taken immediately on waking that can't be moved) — discuss in consultation.
Lifestyle
Protein-first eating (~1.2–1.6 g/kg target weight) and twice-weekly resistance training protect muscle during rapid loss.
Hydrate from minute 31 onward — reduced appetite blunts thirst, and hydration eases the main side effects.
Storage is simple: room temperature below 30°C in the original blister — no fridge, no sharps, and travel is as easy as any other tablet (keep the morning routine on your home clock or adjust gradually across time zones).
If you routinely eat under ~1,200 kcal, tell your clinician; a daily multivitamin is a sensible safeguard during rapid loss.
Long-Term Plan
As with all GLP-1 medicines, appetite returns when treatment stops and regain is common without a plan. Options include continued maintenance dosing, a clinician-guided taper with structured lifestyle support, or switching formats.
One tablet-specific note: because daily dosing clears faster than a weekly injection, effects fade sooner after stopping — another reason to plan rather than drift.
Sources
Pricing
Wegovy tablets are priced per monthly pack, varying by dose strength — [£X] at starting doses to [£X] at 25 mg (typically aligned with the equivalent injection maintenance pricing). Prices include the prescriber consultation, ongoing pharmacist support and free tracked delivery — with no cold-chain constraints, tablets also suit letterbox delivery.
READY TO START?
Complete a free online consultation to find out if Wegovy tablets are right for you. Prescribed by UK clinicians, dispensed by our GPhC-registered pharmacy, delivered free and discreetly.